Cardiovascular disease (CVD) remains a leading cause of death globally and a significant burden on the South African health system. This comprehensive brief, the latest in our NCD series produced by Percept and funded by ASSA, explores the shifting landscape of heart disease. From the biological risks associated with the “double burden” of HIV and ageing to the socioeconomic factors driving hypertension in rural communities, this research provides the evidence base needed for strategic resource allocation. As South Africa moves toward Universal Health Coverage, understanding the nuances of CVD management is critical for sustainable health outcomes. Read the full brief below.